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KMID : 0359319840240020127
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Korean Journal of Veterinary Research
1984 Volume.24 No. 2 p.127 ~ p.136
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Histological Observations of the Parenchymal Organs of the Rats , Rabbits and Dogs Injected with Rompun
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Son Jae-Young
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Abstract
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The present study was carried out to observe the histological changes of the parenchymal organs of the rats, rabbits and dogs intramuscularly injected with Rompun.
The results observed are snmmarized as follows;
The hematologic changes of the rabbits and dogs administered with Rompun were a pronounced decrease in erythrocytes and leucocytes. The percentage of lympocytes was decreased, while that of neutrophils was increased.
There were severe hyperemia of spleen, hyperemia and extention of the central vein of the liver, centrilobular degeneration of liver, hyperemia and hemorrhage of the kidney, necrosis and hydropic degeneration of renal tubule, hyperemia of pulmonary alveolar septa and pulmonary edema. and in the cases injected with Rompun and histamine or pentothal sodium at the same time, the microscopical findings described above were more conspicuous than the cases injected with Rompun alone.
Also in the rabbits injected with Rompun after the intravenous infusion of the chicken erythrocytes, the marked appearances of the chicken erythrocytes in the hyperemic lesions of the each parenchymal organs and the phagocytized chicken erythrocytes by the reticuloendothelial cells were conspicuous.
The degranulations of mast cells were recognized by the administeration of Rompun.
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